Fenestrations of Sarcoplasmic Reticulum

CHICKEN CARDIAC MUSCLE Its Elusive Extended Junctional Sarcoplasmie Reticulum and Sarcoplasmic Reticulum Fenestrations

Fine structure and organization of the sarcoplasmic reticulum in the sino-auricular fibres of frog heart.

The ultrastructure of the sarcoplasmic reticulum (SR) of the sino-auricular fibres of frog heart has been investigated especially in order to evaluate its possible relationship with several cellular organelles. The SR appears as a complex unit which can be divided into three regions:--peripheral SR, localized beneath the sarcolemma. It is composed of junctional SR, which forms specialized compl...

The Effect of Verapamil Administred before the Reperfusion Insult in Isolated Preconditioned Rat Heart on the Microsomal ATPase and Mitochondrial Enzyme Activities

Background: Calcium overload and free radical mediated damage in the mitochondria is the most important pathological changes associated with myocardial ischemic-reperfusion injury. The verapamil post-treatment has been previously reported to prevent reperfusion-induced myocardial injury but functional recovery may be delayed due to the drug's inherent direct myocardial depression effect. In the...

Ultrastructural localization of calsequestrin in adult rat atrial and ventricular muscle cells

The distribution of calsequestrin in rat atrial and ventricular myocardial cells was determined by indirect immunocolloidal gold labeling of ultrathin frozen sections. The results presented show that calsequestrin is confined to the sarcoplasmic reticulum where it is localized in the lumen of the peripheral and the interior junctional sarcoplasmic reticulum as well as in the lumen of the corbul...

Reconstitution of an active calcium pump in sarcoplasmic reticulum.

Recovery of calcium transport and calcium-activated ATPase activity was studied in relation to the retention of protein components in sarcoplasmic reticulum reconstituted after solubilization with deoxycholate and centrifugation, followed by removal of the detergent from the supernatant by dialysis. Control sarcoplasmic reticulum was similarly treated except for omission of deoxycholate. Maximu...